An article in Science recently generated a lot of interest by providing a possible explanation of why COVID-19 can be deadly to some yet go virtually unnoticed in others. Scientists at La Jolla Institute for Immunology in California showed that infection with common cold coronaviruses can generate an immune response that resembles key pieces of the immune response generated by SARS-CoV-2 – the virus that causes COVID-19. This raises the possibility that previous infection with one of the milder coronaviruses could make COVID-19 less severe. But how likely is this? And how does this relate to what we already know…

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